https://www.hayes-lab.com/research daily 0.75 2026-06-11 https://www.hayes-lab.com/research/hypophagia-and-body-weight-loss-by-tirzepatide-are-accompanied-by-fewer-gi-adverse-events-compared-to-semaglutide-in-preclinical-models monthly 0.5 2026-06-11 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1f4214db-5f70-4f42-83a5-fae5ea262b01/sciadv.adu1589-f3.jpg Research - Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models - Make it stand out (A) Semaglutide administration dose-dependently suppresses food intake in rats (10 and 100 nmol/kg, ip; n = 10 per group). (B) The highest tested dose of semaglutide causes significant malaise (i.e., kaolin intake) in rats (100 nmol/kg, ip; n = 10 per group). (C) Semaglutide administration causes body weight loss in a dose-dependent manner (10 and 100 nmol/kg, ip; n = 10 per group). (D) Tirzepatide (TZP) dose-dependently suppress food intake (10 and 100 nmol/kg, ip; n = 10 per group). (E) Systemic administration of tirzepatide (100 nmol/kg) causes significant kaolin intake (ip, n = 10 per group). (F) Tirzepatide dose-dependently suppresses body weight (10 and 100 nmol/kg, ip; n = 10). (G) Tirzepatide and semaglutide induce comparable hypophagic responses in rats compared to controls (100 nmol/kg, ip; n = 10 to 20 per group). (H) Semaglutide administration induces higher kaolin consumption than tirzepatide treatment (100 nmol/kg, ip; n = 10 to 20 per group). (I) Tirzepatide and semaglutide cause similar body weight loss (100 nmol/kg, ip; n = 10 to 20 per group). All data expressed as means ± SEM. Data in (A) to (F) were analyzed with repeated measures two-way ANOVA followed by Tukey’s post hoc tests. Data in (G) to (I) were analyzed with repeated measures mixed-effects model followed by Tukey’s post hoc tests. Means with different letters are significantly different from each other (P < 0.05). https://www.hayes-lab.com/research/the-estrous-cycle-moderates-the-food-and-body-weight-suppressive-effects-of-glucagon-like-peptide-1-receptor-agonism monthly 0.5 2026-06-11 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/9be944a5-5ce6-45eb-8bcb-ce2876b9410b/dom70177-fig-0001-m.jpg Research - The estrous cycle moderates the food and body weight suppressive effects of glucagon-like peptide-1 receptor agonism - Make it stand out In lean female rats, Glp1r expression was greater during combined Proestrus/Estrus (P/E) compared to animals in Metestrus/Diestrus (M/D) in the (A) Nucleus Accumbens, p = 0.0055, (B) Bed Nucleus of the Stria Terminalis, p = 0.0023, (D) Paraventricular Thalamic Nucleus, p = 0.0003, (E) Central Amygdala, p = 0.0016, (F) Arcuate Nucleus, p = 0.0002, and (G) Ventral Tegmental Area, p = 0.045, but not in the (C) Paraventricular Hypothalamic Nucleus, p = 0.378. n = 17–20/group, between-subjects design. p < 0.05; *p < 0.01; ***p < 0.001. https://www.hayes-lab.com/research/gipr-signaling-modulates-pyy-induced-hypophagia-and-malaise-in-rodents monthly 0.5 2026-06-11 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/ed180727-4072-4d46-9989-991cc2f10946/1-s2.0-S2212877826000189-gr2_lrg.jpg Research - GIPR signaling modulates PYY-induced hypophagia and malaise in rodents - Make it stand out Effects of systemic delivered LA-PYY (3, 10, 30, 100 and 300 nmol/kg, IP, n = 9/group) or vehicle on cumulative food intake (A), daily food intake (B) and kaolin intake (B) and body weight (C). Acute treatment with the GIPR agonist GIP-532 (10 nmol/kg, IP) in combination with LA-PYY (100 nmol/kg, IP) does not modify the food intake-suppressive effects (D) or body weight change (F) as seen with LA-PYY treatment alone. However, pre-treatment does attenuate the LA-PYY-induced kaolin intake, with a significant decrease at 24 h and 48 h (E). n = 12–14/group, data are expressed as means ± SEM. Means with different letters are significantly different from each other (P < 0.05) by two-way repeated measures ANOVA with Tukey's multiple comparison tests. https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/135e4098-3590-46b9-9f78-a2c4f09d6f1e/1-s2.0-S2212877826000189-gr3_lrg.jpg Research - GIPR signaling modulates PYY-induced hypophagia and malaise in rodents - Make it stand out A single injection of GIPR antibody GIPG013 (30 mg/kg, IP) does not affect food intake (A), kaolin intake (B), or body weight (C) (n = 12/group). Pre-treatment of the GIPR antibody GIPG013 (30 mg/kg) increases the anorexia from acute LA-PYY (100 nmol/kg) treatment alone, decreasing food intake (C)and reducing body weight (F). However, pre-treatment does not impact the kaolin intake as seen from acute treatment of LA-PYY alone (E) (n = 7–8/group). Data are expressed as means ± SEM. Data in (A and B), analyzed with two-way repeated measures ANOVA, followed by Sidak's multiple comparison tests, data in (D, E, and F) analyzed with two-way repeated measures ANOVA, followed by Tukey's multiple comparison tests, data in (C) tested with an unpaired t test. Means with different letters are significantly different from each other (P < 0.05). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl-h85j6-xwfnn-gcps4 monthly 0.5 2026-05-07 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/a47bb927-ca87-4634-974e-b09c6d621e7d/dom70427-fig-0004-m.jpg Research - GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models - Make it stand out Central TDN in rats and peripheral TDN in mice improves weight and glycemic control. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl-h85j6-xwfnn monthly 0.5 2026-05-07 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/115502de-52bf-4a73-8821-a9365ae1b383/Screenshot+2025-09-17+at+11.55.34%E2%80%AFAM.png Research - Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis - Make it stand out Central TDN in rats and peripheral TDN in mice improves weight and glycemic control. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl-h85j6 monthly 0.5 2025-09-17 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/53ce343b-fb58-4a44-b6c0-6ea2ab3680ca/LC2.png Research - The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1 - Make it stand out LC GLP-1R activation contributes to food intake control via enhanced glutamate signaling. (A) RNAscope analysis did not reveal Glp1r mRNA expression in LC NE neuron (DBH) soma. (B) LC NE neurons express N-methyl-d-aspartate (NMDA) receptors (Grin1A). (C) LC NE neurons express AMPA receptors (GluA1). (D) Pretreatment with an NMDA/AMPA antagonist cocktail [GluR antag; MK-801, 0.05 μg/CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), 0.3 μg] attenuated the food intake-suppressive effects of LC Ex-4 (0.05 μg) at 3 and 6 hours after administration (n = 20). (E) MK-801/CNQX attenuated the food intake suppressive effects of LC Ex-4 at 24 hours (n = 20). (F) Twenty-four-hour body weight reduction by LC Ex-4 was not significantly affected by MK-801/CNQX pretreatment (n = 20). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-3ghmy-n6gf2-rjd5w monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/f2ec7394-df2d-4329-a275-9b0eff92cde3/VTA+amylin+GABA.png Research - Amylin Modulates a Ventral Tegmental Area-to-Medial Prefrontal Cortex Circuit to Suppress Food Intake and Impulsive Food-Directed Behavior - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/0dbce653-1c56-4a96-976d-b33179827319/GIP+.png Research - GIP receptor agonism blocks chemotherapy-induced nausea and vomiting - Make it stand out GIPR agonism attenuates nausea and emesis in 3 different mammalian species. A) GIPR agonism (GIP-532, 3 nmol/kg, SC) blocks retching induced by the chemotherapeutic agent cisplatin (10 mg/kg, IP) in ferrets (n = 5/group). B) While cisplatin (10 mg/kg, IP) produces severe emesis in 4 out of 5 ferrets, pre-treatment with GIPR agonist GIP-523 (3 nmol/kg, SC) completely prevents cisplatin-induced vomiting (n = 5/group). C) GIPR agonism blocks the insurgence of cisplatin-induced emetic episodes (i.e. retching and vomiting) in ferrets (n = 5/group). D) Latency to the first emetic episode following each treatment condition in ferrets. E) In shrews, the profound emesis induced by cisplatin (30 mg/kg, IP) is significantly attenuated by GIP-085 (300 nmol/kg) pre-treatment (n = 8–16/group). F) Cumulative emetic episodes across time in shrews (n = 8–16/group). G) Latency to the first emetic episode following cisplatin treatment with or without GIPR agonist pre-treatment in shrews (n = 6–8/group). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-3ghmy-n6gf2 monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/4884e80e-02da-4eb4-a513-7873f8b598bf/GPR160+fig+5.1.png Research - GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia - Make it stand out DVC Gpr160 KD attenuates 4th icv CART mediated anorexigenic, but not locomotor or core body temperature effects. (A,B) Rats (AAV1-GFP control n = 8; AAV- Gpr160 KD n = 10) were administered 4th icv CART at the onset of the dark cycle and food intake and BW was assessed at the following timepoints 1-, 3-, 6-, 12- and 24-h. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6 monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/18eddd8c-3e2a-4edb-9123-6990851eb853/VTA+satH.png Research - Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights - Make it stand out Satiation hormone signaling mechanisms in the VTA. The distinct mechanisms outlined for each hormone are indicated in the figure, legend, and manuscript text by the first letter of that hormone and the sequential number. A question mark is placed near any mechanisms which are hypothesized. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-3ghmy monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/582742ba-26a7-456f-ad15-a7ab1da1a0d8/tzp+fig+for+website.png Research - Tirzepatide suppresses palatable food intake by selectively reducing preference for fat in rodents - Make it stand out Glucagon-like peptide-1 (GLP-1) receptor knockout eliminates dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonism-induced preference shift between 5-day choice chow and 60% high-fat diet (HFD). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1634060173007-417OZKLLUKRG6YB6YIXQ/fx1_lrg-2+-+Tito+Borner.jpg Research - Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/research/gdf15-induces-an-aversive-visceral-malaise-state-that-drives-anorexia-and-weight-loss monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1633110064575-ZJNJF1AZLH26R681LURW/F2.large-2+-+Tito+Borner.jpg Research - GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist Induced Nausea and Emesis in Preclinical Models - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/research/gdf15-induces-anorexia-through-nausea-and-emesis monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1632944703167-8J00M6XRJW798USSVEPF/1-s2.0-S1550413119306692-fx1_lrg%252B-%252BTito%252BBorner.jpg Research - GDF15 Induces Anorexia through Nausea and Emesis - Make it stand out Borner et al. 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https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1436e6f0-23a2-4241-923c-9f7f27125346/Fortin.jpeg Announcements - Samantha Fortin Awarded a K01 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/announcements/hayes-postdocs-recognized-at-2022-ssib-conference-g4f7s monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/dca06881-a153-410b-9b07-8c356d6e73d9/2023+Endowed+Chair+Ceremony.jpg Announcements - Matt Hayes Recognized as the Albert J. 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