https://www.hayes-lab.com/research daily 0.75 2025-09-17 https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl-h85j6-xwfnn monthly 0.5 2025-09-17 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/115502de-52bf-4a73-8821-a9365ae1b383/Screenshot+2025-09-17+at+11.55.34%E2%80%AFAM.png Research - Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis - Make it stand out Central TDN in rats and peripheral TDN in mice improves weight and glycemic control. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl-h85j6 monthly 0.5 2025-09-17 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/53ce343b-fb58-4a44-b6c0-6ea2ab3680ca/LC2.png Research - The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1 - Make it stand out LC GLP-1R activation contributes to food intake control via enhanced glutamate signaling. (A) RNAscope analysis did not reveal Glp1r mRNA expression in LC NE neuron (DBH) soma. (B) LC NE neurons express N-methyl-d-aspartate (NMDA) receptors (Grin1A). (C) LC NE neurons express AMPA receptors (GluA1). (D) Pretreatment with an NMDA/AMPA antagonist cocktail [GluR antag; MK-801, 0.05 μg/CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), 0.3 μg] attenuated the food intake-suppressive effects of LC Ex-4 (0.05 μg) at 3 and 6 hours after administration (n = 20). (E) MK-801/CNQX attenuated the food intake suppressive effects of LC Ex-4 at 24 hours (n = 20). (F) Twenty-four-hour body weight reduction by LC Ex-4 was not significantly affected by MK-801/CNQX pretreatment (n = 20). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-3ghmy-n6gf2-rjd5w monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/f2ec7394-df2d-4329-a275-9b0eff92cde3/VTA+amylin+GABA.png Research - Amylin Modulates a Ventral Tegmental Area-to-Medial Prefrontal Cortex Circuit to Suppress Food Intake and Impulsive Food-Directed Behavior - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6-thtrl monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/0dbce653-1c56-4a96-976d-b33179827319/GIP+.png Research - GIP receptor agonism blocks chemotherapy-induced nausea and vomiting - Make it stand out GIPR agonism attenuates nausea and emesis in 3 different mammalian species. A) GIPR agonism (GIP-532, 3 nmol/kg, SC) blocks retching induced by the chemotherapeutic agent cisplatin (10 mg/kg, IP) in ferrets (n = 5/group). B) While cisplatin (10 mg/kg, IP) produces severe emesis in 4 out of 5 ferrets, pre-treatment with GIPR agonist GIP-523 (3 nmol/kg, SC) completely prevents cisplatin-induced vomiting (n = 5/group). C) GIPR agonism blocks the insurgence of cisplatin-induced emetic episodes (i.e. retching and vomiting) in ferrets (n = 5/group). D) Latency to the first emetic episode following each treatment condition in ferrets. E) In shrews, the profound emesis induced by cisplatin (30 mg/kg, IP) is significantly attenuated by GIP-085 (300 nmol/kg) pre-treatment (n = 8–16/group). F) Cumulative emetic episodes across time in shrews (n = 8–16/group). G) Latency to the first emetic episode following cisplatin treatment with or without GIPR agonist pre-treatment in shrews (n = 6–8/group). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-3ghmy-n6gf2 monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/4884e80e-02da-4eb4-a513-7873f8b598bf/GPR160+fig+5.1.png Research - GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia - Make it stand out DVC Gpr160 KD attenuates 4th icv CART mediated anorexigenic, but not locomotor or core body temperature effects. (A,B) Rats (AAV1-GFP control n = 8; AAV- Gpr160 KD n = 10) were administered 4th icv CART at the onset of the dark cycle and food intake and BW was assessed at the following timepoints 1-, 3-, 6-, 12- and 24-h. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-7cdm6 monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/18eddd8c-3e2a-4edb-9123-6990851eb853/VTA+satH.png Research - Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights - Make it stand out Satiation hormone signaling mechanisms in the VTA. The distinct mechanisms outlined for each hormone are indicated in the figure, legend, and manuscript text by the first letter of that hormone and the sequential number. A question mark is placed near any mechanisms which are hypothesized. https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis-3ghmy monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/582742ba-26a7-456f-ad15-a7ab1da1a0d8/tzp+fig+for+website.png Research - Tirzepatide suppresses palatable food intake by selectively reducing preference for fat in rodents - Make it stand out Glucagon-like peptide-1 (GLP-1) receptor knockout eliminates dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonism-induced preference shift between 5-day choice chow and 60% high-fat diet (HFD). https://www.hayes-lab.com/research/corrination-of-a-glp-1-receptor-agonist-for-glycemic-control-without-emesis monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1634060173007-417OZKLLUKRG6YB6YIXQ/fx1_lrg-2+-+Tito+Borner.jpg Research - Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/research/gdf15-induces-an-aversive-visceral-malaise-state-that-drives-anorexia-and-weight-loss monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1633110064575-ZJNJF1AZLH26R681LURW/F2.large-2+-+Tito+Borner.jpg Research - GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist Induced Nausea and Emesis in Preclinical Models - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.hayes-lab.com/research/gdf15-induces-anorexia-through-nausea-and-emesis monthly 0.5 2024-08-06 https://images.squarespace-cdn.com/content/v1/60df607bb8a6da20f8129dc4/1632944703167-8J00M6XRJW798USSVEPF/1-s2.0-S1550413119306692-fx1_lrg%252B-%252BTito%252BBorner.jpg Research - GDF15 Induces Anorexia through Nausea and Emesis - Make it stand out Borner et al. 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